The muscle pain statin drugs cause is directly related to the way statin drugs work. This substance helps your muscles produce energy. Some people are more likely to develop side effects from statins, including muscle pain. Here's how to enhance your abdominal muscles for visible results. Both of these actions help to lower your total cholesterol level. As with many people who take prescription medications, some people who use statins experience side effects. When it comes to gaining lean muscle, what you eat matters. However, the most common side effect is muscle pain … They cause muscle pain in under 5% of the people who take them, and these pains often stop by themselves even with continued statin … Your doctor will likely also test your blood for increased creatine kinase (CK) levels—an indicator of rhabdomyolysis. Lee D, Goldberg A. Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common. However, taking high doses of statins or taking them with certain other drugs can increase your risk of this condition. 'Statins DO cause muscle pain - I've seen it first hand': Physiotherapist says the drugs affect some of her patients so much they're barely able to move Sammy Margo is a chartered … But, we do know that there are various levels of … Pregabalin (Lyrica) is prescribed for certain kinds … Looking to start a diet to better manage your cholesterol? It's thought that simvastatin (Zocor) may be more likely to cause muscle pain as a side effect than other statins when it's taken at high doses. Some increase the likelihood of muscle pain or rhabdomyolysis when taken with a statin. Statins are a common group of drugs prescribed by doctors to treat high cholesterol. While there are several theories as to why statins may cause muscle pain, none have been confirmed. Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. doi:10.1186/1476-511X-11-40, Rosenson RS, Baker SK, Jacobson TA, et al. Can Cinnamon Improve the Health or Looks of Your Hair? Tasks that were once simple, such as climbing stairs or walking, may make you uncomfortable and tired while using statins. J Am Heart Assoc. Phys Ther. The following are the three most common forms of statin-related muscle pain: Muscle problems related to statin therapy usually begin within a few weeks to a few months after beginning treatment. Your doctor may lower your dosage or prescribe a different statin. The Mayo Clinic suggest… High-dose simvastatin (brand name Zocor) appears to present a higher risk for muscle pain than other statin drugs. Other reported side effects of statins include liver or digestive problems, high blood sugar, type 2 diabetes, and memory problems. Here's what may be possible and what's unlikely. Also avoid using over-the-counter pain relievers. In rare cases, the impact of these drugs on the muscles can be serious. Harvard Health Publishing. doi:10.1161/JAHA.118.009835, Thompson PD, Panza G, Zaleski A, Taylor B. Statin-associated side effects. Statins also enable your liver to remove cholesterol from your blood. As many are aware, statins can cause unpleasant muscle sensations, such as stiffness and tenderness, for reasons still unknown. Sometimes this pain can be a sign of damage, which can be severe. This article takes a look at the top 26 muscle-building foods. In addition to severe muscle pain, rhabdomyolysis can lead to liver damage, kidney failure, and, in rare cases, death. About 5% to 10% of patients taking statins experience SAMS or mild muscle pain. Your risk of experiencing SAMS while taking statins is increased if you: Statin-related muscle problems are more likely to occur in people who exercise vigorously, especially if they begin to do so at a rapid rate rather than slowly building up intensity., It is also more common in people taking a variety of other medications, including Lopid (gemfibrozil), as well as steroids, cyclosporine, or niacin., Furthermore, studies have also shown that people with vitamin D deficiency also tend to experience muscle problems with statins more frequently than others. Coenzyme Q10. SAMS can vary in frequency and severity. Nerve pain / anti-seizure medication — pregabalin. Here are 7 reasons to avoid greasy food. An assessment by the statin muscle safety task force: 2014 update. Benefits and How to Use Them. Your doctor may even prescribe a non-statin drug to help lower your cholesterol. Statin therapy, myopathy and exercise–a case report. Effects of statins on skeletal muscle: a perspective for physical therapists. People who take statins and drink large quantities of grapefruit juice may be at increased risk for muscular side effects. What You Need to Know About Arteriosclerosis, What You Should Know About Statin Drug Interactions, Finding the Potential Side Effects of Taking Medication, How Different Drugs Can Help Lower Your Cholesterol, Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common, Effects of statins on skeletal muscle: a perspective for physical therapists, Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trials, Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management, Statin therapy, myopathy and exercise–a case report, An assessment by the statin muscle safety task force: 2014 update, The relationship of vitamin D deficiency to statin myopathy, Amyotrophic lateral sclerosis associated with statin use: A disproportionality analysis of the FDA's adverse event reporting system, National trends in statin use and expenditures in the U.S. adult population From 2002 to 2013: Insights from the Medical Expenditure Panel Survey, Have certain conditions like hypothyroidism, Consume large amounts of grapefruit or cranberry juice. The balance sheet for Crestor and other statins looks like this: These drugs cut the risk of heart attack, angina (chest pain), stroke, and death from cardiovascular disease by 30%. Your doctor may take you off of the statin for a while to see how your body responds. He should be advised to speak to his cardiologist. The muscle cramps, muscle ache, muscle twitch, muscle pain, muscle soreness that Lipitor and Statins cause is primarily from Lipitor's interaction with the body: it depletes the body of Magnesium. Statin use has also been associated with difficulties with memory and reasoning, although there is no clear evidence that the drugs were responsible. Research has suggested that taking CoQ10 supplements might lower your chances of experiencing statin-related myopathy, but available data is still not sufficient enough to back this up. The meals are low calorie but not low on flavor. People taking cholesterol lowering drugs called statins are 30 percent more likely to develop a serious back disorder. For example, avoid exercising too much. Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trials. Because of these benefits, the decision to stop taking statins because of related muscle pain is carefully considered. Research has shown that the gene atrogin-1 may be the source of muscle pain in those taking statins. An international team of BHF-funded researchers may have discovered why some people experience muscle pain after taking statins. Jennifer Moll, MS, PharmD, is a pharmacist actively involved in educating patients about the importance of heart disease prevention. N Engl J Med. How statins cause muscle pain is not fully understood. Changing lifelong eating habits can be scary at first, but our guide will make it easier. Sometimes, but not always, they can cause muscle inflammation as well, with evidence of muscle breakdown in the blood. Some experts have reported that administering vitamin D to these people helps ease these symptoms., People who have the muscle disease amyotrophic lateral sclerosis (ALS) are also at higher risk for muscle pain while taking statins., Millions of Americans take statins because they effectively target all aspects of one's lipid profile by lowering low-density lipoprotein (LDL) cholesterol and triglycerides while raising high-density lipoprotein (HDL) cholesterol. The research, published in JACC: Basic to Translational … How Thyroid Disease Affects Cholesterol (and Vice Versa), Side Effects of Statin Drugs for Cholesterol, How Zocor (Simvastatin) Works to Lower Your Cholesterol, Everything You Need To Know About Juvenile Myositis. J Clin Lipidol 2014; 8:S58. Harvard Medical School. In general, muscle symptoms directly due to a statin drug cause diffuse muscle aches. While statin-related myalgia, myositis, and rhabdomyolysis will resolve once you stop taking statins, rhabdomyolysis may result in irreversible muscle damage. Circ Res. UpToDate. Muscle aches on statin drugs like Lipitor are common. These findings were published in the Journal of … Mammen AL. Eur Heart J. Can Statins Increase Lung Cancer Survival? Another theory is that statins … Genetics. What Is a Drop Set? The risk appears to be significantly lower with Lescol (fluvastatin), Pravachol (pravastatin) and Crestor (rosuvastatin). Although your muscle pain could be caused by the drug, it might be caused by something else. These include having: Your risk of side effects is also higher if you take many different cholesterol drugs at the same time. 2016;67(20):2395-2410. doi:10.1016/j.jacc.2016.02.071, Ward NC, Watts GF, Eckel RH. The pain … These tips will get you started. A thin frame featuring low body fat will not be enough to get 6-pack abs. Crestor: Uses, Side Effects, Dosages, Interactions, Treating an Underlying Thyroid Disorder Can Relieve Muscle Symptoms. Certain factors may increase this risk. Answer. As with any drug, you should bring up any concerns you have with your doctor to ensure that this is still the right treatment plan for you, and you should never stop taking a prescribed medication without your doctor's OK. You ignored the fact that he was on a high dose of atorvastatin (80 mg). 2012;11(40). While there are several theories as to why statins may cause muscle pain, none have been confirmed. One of these side effects is muscle pain. However this affects all muscles in the body - not just muscles … It's … 2011;215(1):23-9. doi:10.1016/j.atherosclerosis.2010.11.039, Golomb BA, Verden A, Messner AK, Koslik HJ, Hoffman KB. Muscle pain associated with statins may be mild and uncomfortable or significant enough to impact daily life. Here’s Where COVID-19 Cases Are Rising and Falling. 2015;36(17):1012-1022. doi:10.1093/eurheartj/ehv043, Semple, SJ. Another theory is that statins decrease the levels of a natural substance in your body called coenzyme Q10. Here are 30 science-backed methods to help you reach your goal of a flat…. Our website services, content, and products are for informational purposes only. Losing the fat around your midsection can be a battle, but it is possible. I wondered if is is possible the Statin drugs do inhibit the work of arthritis meds? Muscle pain is the most common side effect of statin drugs. They may suggest stopping treatment only briefly until the problem resolves, or not at all. During this time, diabetes may seem…. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. About 25 million Americans take statins. Rhabdomyolysis. The negative effects of statins on muscles may be more common in individuals with prior muscle issues, and this could explain why these side effects show up more frequently in real life than they do in controlled tests. Lipids Health Dis. If you have muscle pain while you take a statin, tell your doctor right away. When the drug is removed from the cells, it does not appear to cause muscle damage. In the future, this may allow your healthcare professional to identify if you are at risk for statin-related muscle pain. While greatly beneficial to many people working to manage hyperlipidemia, like all drugs, statins come with the risk of side effects. Lowering your dose may … 2011;109(2):123-6. doi:10.1161/CIRCRESAHA.111.248872, Di stasi SL, Macleod TD, Winters JD, Binder-macleod SA. Research has also shown that people taking Mevacor (lovastatin) have higher levels of atrogin-1 than those not taking the drug. Updated August 1, 2017. Greasy food is scrumptious and quick, but you may wonder what effect it has on your body. She is an assistant clinical professor of Medicine at Vanderbilt University School of Medicine and an award-winning physician writer. While it may be likely that it is indeed the drug that is causing your discomfort, they will consider the possibility of other causes as well. Research has also shown that people taking Mevacor (lovastatin) have higher levels o… As you correctly imply, statins are indeed associated with muscle pain and inflammation. Statins are very effective. Statins are more likely to cause muscle pain when taken at high doses or when taken in combination with certain medications. Healthline Media does not provide medical advice, diagnosis, or treatment. This serious muscle wasting condition is rare and occurs in a fraction of patients. Circ Res. Last medically reviewed on February 2, 2017. Rhabdomyolysis, or the breakdown of muscle tissue, is a rare side effect of statins that can also cause muscle pain. In fact, we don’t understand the mechanism ( there are theories ). Atherosclerosis. Those include other cholesterol-lowering drugs such as gemfibrozil and niacin; drugs to lower blood … Experts say they’re encouraged by the downward trend in COVID-19 cases, but they remain concerned about a new surge. 2017;2(1):56-65. doi:10.1001/jamacardio.2016.4700. Drug Saf. Muscle complaints have been documented to increase with increasing blood levels of the statin. J Am Coll Cardiol. 2019;124(2):328-350. doi:10.1161/CIRCRESAHA.118.312782, Stroes E, Thompson P, Corsini A et al. They also reduce the chance of stroke and heart attack.. Besides muscle pain, these can include liver damage, digestive problems, increased blood sugar, memory loss and confusion.. … According to research recently published in the … 2016;374(7):664-9. doi:10.1056/NEJMra1515161, An Overview of Muscle Pain in Statin Users, Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved. MONDAY, June 3 (HealthDay News) -- People taking statin drugs to lower their cholesterol may slightly increase their risk for muscle and joint diseases as well as strains and sprains, a new … His joint pain might be due to the statin. The reasons why the older statins caused higher rates of muscle pain are not really clear, but part of … Although statins are lipid-lowering drugs that block cholesterol biosynthesis, but also exert immunomodulatory, anti … Another theory is that statins can potentially interfere with the production of CoQ10, a coenzyme in the muscles. CoQ10 assists the muscles in using the energy they need to function properly.
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